This was an interesting talk by Michelle Levesque. She wanted to write a Python webapp and went to get one for her project. Surely, there is one available.
Actually... there isn't one. Kinda too bad. There are about 40 instead. Then she faced the dilemma of "which to choose?" And that's when she started the "web-off". Have a big comparison among some of the big players to see what works best.
The talk briefly described four of the seven approaches that she is looking at. She has more details on the results so far, along with a blog of results as she goes.
Very interesting talk. Personally, I don't use any of those as they generally mix the HTML output and the Python code too much.